BELHOCINE Mohamed, PhD

International publications (19)

• DNA methylation as a new tool for the differential diagnosis between T-LBL and lymphocyte-rich thymoma.
  (27 September 2024 - The Journal of Pathology - Impact factor: 5.600)
  Mehdi Latiri *, Mohamed Belhocine *, Charlotte Smith, Nathalie Garnier, Estelle Balducci, Antoine Pinton, Guillaume P Andrieu, Julie Bruneau , Salvatore Spicuglia, Stéphane Jamain, Violaine Latapie,Vincent Thomas de Montpreville, Lara Chalabreysse, Alexander Marx, Nicolas Girard, Benjamin Besse, Christoph Plass, Laure Gibault, Cécile Badoual, Elizabeth Macintyre, Vahid Asnafi, Thierry Jo Molina and Aurore Touzart.
  * Equal contributors.
  
  
• Dynamic of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes.
  (June 2022 - Genome Research - Impact factor: 9.043)
  Mohamed Belhocine, Mathieu Simonin, José David Abad Flores, Agata Cieslak, Iris Manosalva, Lydie Pradel, Charlotte Smith, Eve-Lyne Mathieu, Guillaume Charbonnier, Joost H.A. Martens, Hendrik G. Stunnenberg, Muhammad Ahmad Maqbool, Aneta Mikulasova, Lisa J. Russell, Daniel Rico, Denis Puthier, Pierre Ferrier, Vahid Asnafi and Salvatore Spicuglia.
  
  
• A Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation.
  (June 2021 - Journal of Experimental Medicine - Impact factor: 14.307)
  Agata Cieslak, Guillaume Charbonnier, Melania Tesio, Eve-Lyne Mathieu, Mohamed Belhocine, Aurore Touzart, Charlotte Smith, Guillaume Hypolite, Guillaume P Andrieu, Joost Martens, Eva Janssen-Megens, Marta Gut, Ivo Gut, Nicolas Boissel, Arnaud Petit, Denis Puthier, Elizabeth Macintyre, Henk Stunnenberg, Salvatore Spicuglia.
  
  
• A Transcriptomic Continuum of Differentiation Arrest in Acute Leukemia.
  (May 2020 - Leukemia - Impact factor: 11.528)
  Jonathan Bond, Aleksandra Krzywon, Ludovic Lhermitte, Christophe Roumier, Anne Roggy, Mohamed Belhocine, Alexander Kheirallah, Patrick Villarese, Guillaume Hypolite, Francine Garnache-Ottou, Herve Dombret, Nicolas Boissel, Claude Preudhomme, Vahid Asnafi, Elisa Laurenti, Elizabeth Macintyre
  
  
• Low level CpG island promoter methylation predicts a poor outcome in adult T-cell acute lymphoblastic leukemia.
  (September 2019 - Haematologica - Impact factor: 9.941)
  Touzart A, Boissel N, Belhocine M, Smith C, Graux C, Latiri M, Lhermitte L, Mathieu EL, Huguet F, Lamant L, Ferrier P, Ifrah N, Macintyre E, Dombret H, Asnafi V and Spicuglia S.
  
  
• A critical regulator of Bcl2 revealed by systematic transcript discovery of lncRNAs associated with T-cell differentiation.
  (18 March 2019 - Scientific Reports - Impact factor: 4.379)
  Wiam Saadi, Yasmina Kermezli, Lan T. M. Dao, Evelyne Mathieu, David Santiago-Algarra, Iris Manosalva, Magali Torres, Mohamed Belhocine, Lydie Pradel, Beatrice Loriod, Mourad Aribi, Denis Puthier & Salvatore Spicuglia
  
  
• Explore, edit and leverage genomic annotations using Python GTF toolkit
  (Feb 2019 - Bioinformatics - Impact factor: 6.937)
  F. Lopez, G. Charbonnier, Y. Kermezli, M. Belhocine, Q. Ferré, N. Zweig, M. Aribi, A. Gonzalez, S. Spicuglia, D. Puthier
  
  
• Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL
  (Dec 2018 - Clinical Cancer Research - Impact factor: 12.531)
  Dr. Aurore Touzart , Dr. Etienne Lengline , Mr. Mehdi Latiri , Dr. Mohamed Belhocine , Charlotte Smith , Dr. Xavier Thomas , Dr. Salvatore Spicuglia , Dr. Denis Puthier , Dr. Françoise Pflumio , Dr. Thibaut Leguay , Dr. Carlos Graux , Dr. Yves Chalandon , Dr. Francoise Huguet , Dr. stéphane leprêtre , Dr. Norbert Ifrah , Dr. Hervé Dombret , Dr. Elizabeth Macintyre , Dr. Mathilde Hunault-Berger , Dr. Nicolas Boissel
  
  
• A comprehensive catalog of LncRNAs expressed in T-Cell Acute Lymphoblastic Leukemia.
  (Nov 2018 - Leukemia & Lymphoma Journal - Impact factor: 3.280)
  Yasmina Kermezli, Wiam Saadi, Mohamed Belhocine, Eve-Lyne Mathieu, Marc-Antoine Garibal, Vahid Asnafi, Mourad Aribi, Salvatore Spicuglia and Denis Puthier.
  
  
• Novel Intergenically-spliced Chimera, NFATC3-PLA2G15, is Associated with Aggressive T-ALL Biology and Outcome.
  (Jan 2018 - Molecular Cancer Research - Impact factor: 5.852)
  Jonathan Bond, Christine Tran Quang, Guillaume Hypolite, Mohamed Belhocine, Aurélie Bergon, Gaëlle Cordonnier, Jacques Ghysdael, Elizabeth Macintyre, Nicolas Boissel, Salvatore Spicuglia and Vahid Asnafi.
  
  
• Early response-based therapy stratification improves survival in adult ETP-ALL: a GRAALL study.
  (Jun 2017 - Journal of Clinical Oncology - Impact factor: 44.544)
  Jonathan Bond, Carlos Graux, Ludovic Lhermitte, Diane Lara, Thomas Cluzeau, thibaut leguay, Agata Cieslak, Amélie Trinquand, Cedric Pastoret, Mohamed Belhocine, Salvatore Spicuglia, Véronique LHERITIER, Stéphane Leprêtre, Xavier Thomas, RIGAL-HUGUET Françoise, Ifrah Norbert, Herve Dombret, Elizabeth Macintyre, Nicolas Boissel, and Vahid Asnafi.
  
  
• TCR rearrangments identify a subgroup of NKL-deregulated adult T-ALLs associated with favorable outcome.
  (Jun 2017 - Leukemia - Impact factor: 11.528)
  P Villarese, C Lours, A Trinquand, S Le Noir, M Belhocine, L Lhermitte, A Cieslak, M Tesio, A Petit, M LeLorch, S Spicuglia, N Ifrah, H Dombret, A W Langerak, N Boissel, E Macintyre & V Asnafi.
  
  
• Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia.
  (April 2017 - Blood - Impact factor: 22.113)
  Laurent Renou, Pierre-Yves Boelle, Caroline Deswarte, Salvatore Spicuglia, Aissa Benyucef, Julien Calvo, Benjamin Uzan, Mohamed Belhocine, Agata Cieslak, Judith Landman-Parker, Andre Baruchel, Vahid Asnafi, Françoise Pflumio, Paola Ballerini, and Irina Naguibneva.
  
  
• CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis.
  (Feb 2017 - Leukemia - Impact factor: 11.528)
  Cordonnier G, Mandoli A, Radhouane A, Hypolite G, Lhermitte L, Belhocine M , Asnafi V, Macintyre E, Martens JH, Fumagalli S, Bond J.
  
  
• Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia.
  (Jun 2016 - Cancer Discovery - Impact factor: 39.397)
  Amélie Trinquand, Nuno R. dos Santos, Christine Tran Quang, Francesca Rocchetti, Benedetta Zaniboni, Mohamed Belhocine, Cindy Da Costa de Jesus, Ludovic Lhermitte, Melania Tesio, Michael Dussiot, François-Loïc Cosset, Els Verhoeyen, Françoise Pflumio, Norbert Ifrah, Hervé Dombret, Salvatore Spicuglia, Lucienne Chatenoud, David-Alexandre Gross, Olivier Hermine, Elizabeth Macintyre, Jacques Ghysdae, and Vahid Asnafi.
  
  
• Transcription dependent generation of a specialized chromatin structure at the Tcrβ locus.
  (Feb 2015 - Journal of immunology - Impact factor: 5.422)
  Belhocine M*,Zacarias-Cabeza J*,Vanhille L, Cauchy P, Koch F, Pekowska A, Fenouil R, Bergon A, Gut M, Gut I, Eick D, Imbert J, Ferrier P, Andrau JC and Spicuglia S.
  * Equal contributors.
  
  
• Functions of lncRNA in development and diseases.
  (Sep 2014 - Médecine/Sciences - Impact factor: 0.818)
  Eve-Lyne Mathieu, Mohamed Belhocine, Lan T.M. Dao, Denis Puthier, Salvatore Spicuglia.
  
  
• Divergent transcription is associated with promoters of transcriptional regulators.
  (Dec 2013 - BMC Genomics - Impact factor: 3.969)
  Belhocine M*, Lepoivre C*, Bergon A, Griffon A, Yammine M, Vanhille L, Zacarias-Cabeza J, Garibal MA, Koch F, Maqbool MA, Fenouil R, Loriod B, Holota H, Gut M, Gut I, Imbert J, Andrau JC, Puthier D, Spicuglia S.
  * Equal contributors.
  
  
• H3K4 tri-methylation provides an epigenetic signature of active enhancers.
  (Jul2011 - EMBO Journal - Impact factor: 11.598)
  Aleksandra Pekowska, Touati Benoukraf, Joaquin Zacarias Cabeza, Mohamed Belhocine, Frederic Koch, Hélène Holota, Jean Imbert, Jean-Christophe Andrau, Pierre Ferrier and Salvatore Spicuglia.