BELHOCINE Mohamed, PhD

International publications (18)

• Dynamic of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes.
  (June 2022 - Genome Research - Impact factor: 9.043)
  Mohamed Belhocine, Mathieu Simonin, José David Abad Flores, Agata Cieslak, Iris Manosalva, Lydie Pradel, Charlotte Smith, Eve-Lyne Mathieu, Guillaume Charbonnier, Joost H.A. Martens, Hendrik G. Stunnenberg, Muhammad Ahmad Maqbool, Aneta Mikulasova, Lisa J. Russell, Daniel Rico, Denis Puthier, Pierre Ferrier, Vahid Asnafi and Salvatore Spicuglia.
  
  
• A Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation.
  (June 2021 - Journal of Experimental Medicine - Impact factor: 14.307)
  Agata Cieslak, Guillaume Charbonnier, Melania Tesio, Eve-Lyne Mathieu, Mohamed Belhocine, Aurore Touzart, Charlotte Smith, Guillaume Hypolite, Guillaume P Andrieu, Joost Martens, Eva Janssen-Megens, Marta Gut, Ivo Gut, Nicolas Boissel, Arnaud Petit, Denis Puthier, Elizabeth Macintyre, Henk Stunnenberg, Salvatore Spicuglia.
  
  
• A Transcriptomic Continuum of Differentiation Arrest in Acute Leukemia.
  (May 2020 - Leukemia - Impact factor: 11.528)
  Jonathan Bond, Aleksandra Krzywon, Ludovic Lhermitte, Christophe Roumier, Anne Roggy, Mohamed Belhocine, Alexander Kheirallah, Patrick Villarese, Guillaume Hypolite, Francine Garnache-Ottou, Herve Dombret, Nicolas Boissel, Claude Preudhomme, Vahid Asnafi, Elisa Laurenti, Elizabeth Macintyre
  
  
• Low level CpG island promoter methylation predicts a poor outcome in adult T-cell acute lymphoblastic leukemia.
  (September 2019 - Haematologica - Impact factor: 9.941)
  Touzart A, Boissel N, Belhocine M, Smith C, Graux C, Latiri M, Lhermitte L, Mathieu EL, Huguet F, Lamant L, Ferrier P, Ifrah N, Macintyre E, Dombret H, Asnafi V and Spicuglia S.
  
  
• A critical regulator of Bcl2 revealed by systematic transcript discovery of lncRNAs associated with T-cell differentiation.
  (18 March 2019 - Scientific Reports - Impact factor: 4.379)
  Wiam Saadi, Yasmina Kermezli, Lan T. M. Dao, Evelyne Mathieu, David Santiago-Algarra, Iris Manosalva, Magali Torres, Mohamed Belhocine, Lydie Pradel, Beatrice Loriod, Mourad Aribi, Denis Puthier & Salvatore Spicuglia
  
  
• Explore, edit and leverage genomic annotations using Python GTF toolkit
  (Feb 2019 - Bioinformatics - Impact factor: 6.937)
  F. Lopez, G. Charbonnier, Y. Kermezli, M. Belhocine, Q. Ferré, N. Zweig, M. Aribi, A. Gonzalez, S. Spicuglia, D. Puthier
  
  
• Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL
  (Dec 2018 - Clinical Cancer Research - Impact factor: 12.531)
  Dr. Aurore Touzart , Dr. Etienne Lengline , Mr. Mehdi Latiri , Dr. Mohamed Belhocine , Charlotte Smith , Dr. Xavier Thomas , Dr. Salvatore Spicuglia , Dr. Denis Puthier , Dr. Françoise Pflumio , Dr. Thibaut Leguay , Dr. Carlos Graux , Dr. Yves Chalandon , Dr. Francoise Huguet , Dr. stéphane leprêtre , Dr. Norbert Ifrah , Dr. Hervé Dombret , Dr. Elizabeth Macintyre , Dr. Mathilde Hunault-Berger , Dr. Nicolas Boissel
  
  
• A comprehensive catalog of LncRNAs expressed in T-Cell Acute Lymphoblastic Leukemia.
  (Nov 2018 - Leukemia & Lymphoma Journal - Impact factor: 3.280)
  Yasmina Kermezli, Wiam Saadi, Mohamed Belhocine, Eve-Lyne Mathieu, Marc-Antoine Garibal, Vahid Asnafi, Mourad Aribi, Salvatore Spicuglia and Denis Puthier.
  
  
• Novel Intergenically-spliced Chimera, NFATC3-PLA2G15, is Associated with Aggressive T-ALL Biology and Outcome.
  (Jan 2018 - Molecular Cancer Research - Impact factor: 5.852)
  Jonathan Bond, Christine Tran Quang, Guillaume Hypolite, Mohamed Belhocine, Aurélie Bergon, Gaëlle Cordonnier, Jacques Ghysdael, Elizabeth Macintyre, Nicolas Boissel, Salvatore Spicuglia and Vahid Asnafi.
  
  
• Early response-based therapy stratification improves survival in adult ETP-ALL: a GRAALL study.
  (Jun 2017 - Journal of Clinical Oncology - Impact factor: 44.544)
  Jonathan Bond, Carlos Graux, Ludovic Lhermitte, Diane Lara, Thomas Cluzeau, thibaut leguay, Agata Cieslak, Amélie Trinquand, Cedric Pastoret, Mohamed Belhocine, Salvatore Spicuglia, Véronique LHERITIER, Stéphane Leprêtre, Xavier Thomas, RIGAL-HUGUET Françoise, Ifrah Norbert, Herve Dombret, Elizabeth Macintyre, Nicolas Boissel, and Vahid Asnafi.
  
  
• TCR rearrangments identify a subgroup of NKL-deregulated adult T-ALLs associated with favorable outcome.
  (Jun 2017 - Leukemia - Impact factor: 11.528)
  P Villarese, C Lours, A Trinquand, S Le Noir, M Belhocine, L Lhermitte, A Cieslak, M Tesio, A Petit, M LeLorch, S Spicuglia, N Ifrah, H Dombret, A W Langerak, N Boissel, E Macintyre & V Asnafi.
  
  
• Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia.
  (April 2017 - Blood - Impact factor: 22.113)
  Laurent Renou, Pierre-Yves Boelle, Caroline Deswarte, Salvatore Spicuglia, Aissa Benyucef, Julien Calvo, Benjamin Uzan, Mohamed Belhocine, Agata Cieslak, Judith Landman-Parker, Andre Baruchel, Vahid Asnafi, Françoise Pflumio, Paola Ballerini, and Irina Naguibneva.
  
  
• CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis.
  (Feb 2017 - Leukemia - Impact factor: 11.528)
  Cordonnier G, Mandoli A, Radhouane A, Hypolite G, Lhermitte L, Belhocine M , Asnafi V, Macintyre E, Martens JH, Fumagalli S, Bond J.
  
  
• Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia.
  (Jun 2016 - Cancer Discovery - Impact factor: 39.397)
  Amélie Trinquand, Nuno R. dos Santos, Christine Tran Quang, Francesca Rocchetti, Benedetta Zaniboni, Mohamed Belhocine, Cindy Da Costa de Jesus, Ludovic Lhermitte, Melania Tesio, Michael Dussiot, François-Loïc Cosset, Els Verhoeyen, Françoise Pflumio, Norbert Ifrah, Hervé Dombret, Salvatore Spicuglia, Lucienne Chatenoud, David-Alexandre Gross, Olivier Hermine, Elizabeth Macintyre, Jacques Ghysdae, and Vahid Asnafi.
  
  
• Transcription dependent generation of a specialized chromatin structure at the Tcrβ locus.
  (Feb 2015 - Journal of immunology - Impact factor: 5.422)
  Belhocine M*,Zacarias-Cabeza J*,Vanhille L, Cauchy P, Koch F, Pekowska A, Fenouil R, Bergon A, Gut M, Gut I, Eick D, Imbert J, Ferrier P, Andrau JC and Spicuglia S.
  * Equal contributors.
  
  
• Functions of lncRNA in development and diseases.
  (Sep 2014 - Médecine/Sciences - Impact factor: 0.818)
  Eve-Lyne Mathieu, Mohamed Belhocine, Lan T.M. Dao, Denis Puthier, Salvatore Spicuglia.
  
  
• Divergent transcription is associated with promoters of transcriptional regulators.
  (Dec 2013 - BMC Genomics - Impact factor: 3.969)
  Belhocine M*, Lepoivre C*, Bergon A, Griffon A, Yammine M, Vanhille L, Zacarias-Cabeza J, Garibal MA, Koch F, Maqbool MA, Fenouil R, Loriod B, Holota H, Gut M, Gut I, Imbert J, Andrau JC, Puthier D, Spicuglia S.
  * Equal contributors.
  
  
• H3K4 tri-methylation provides an epigenetic signature of active enhancers.
  (Jul2011 - EMBO Journal - Impact factor: 11.598)
  Aleksandra Pekowska, Touati Benoukraf, Joaquin Zacarias Cabeza, Mohamed Belhocine, Frederic Koch, Hélène Holota, Jean Imbert, Jean-Christophe Andrau, Pierre Ferrier and Salvatore Spicuglia.